Ncor2 | nuclear receptor co-repressor 2
Physiological systems
22 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Cardiovascular system Craniofacial Mortality/aging
11 No significant impact
2 Not tested
Data collections
Gene metrics:16Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| edema | 1 supporting dataset | Ncor2em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| long tibia | 1 supporting dataset | Ncor2Ncor2 | heterozygote | Early adult | 1.53x10-6 | ||
| increased startle reflex | 3 supporting datasets | Ncor2Ncor2 | homozygote | Early adult | 1.93x10-11 | ||
| abnormal blood vessel morphology | 1 supporting dataset | Ncor2em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Ncor2Ncor2 | homozygote | Early adult | N/A * | ||
| abnormal craniofacial morphology | 1 supporting dataset | Ncor2em1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Ncor2em1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| abnormal tail movements | 1 supporting dataset | Ncor2Ncor2 | heterozygote | Early adult | 1.7x10-5 | ||
| increased prepulse inhibition | 3 supporting datasets | Ncor2Ncor2 | heterozygote | Early adult | 1.32x10-6 | ||
| abnormal placenta morphology | 1 supporting dataset | Ncor2em1(IMPC)Mbp | homozygote | E15.5 | N/A * |
| | | | | | | | | | |
Human diseases caused by Ncor2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Ncor2.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Ncor2em1(IMPC)Mbp | Exon Deletion | | mouse |
| Ncor2tm96110(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |